On a house-tower at least from the fourteenth century, traditionally belonging to the Caminesi and perhaps to the same Gaia mentioned by Dante (Purg. XVI, 140), the Persico family built their palace during the 15th century, enriching it between 1496 and 1506 with a rusticated stone façade, allegorical figures, and zodiac signs that represent the peak of Belluno's civil architecture of the Renaissance.
Purchased by the historian Giorgio Piloni in 1596, it was for years at the center of a lengthy legal dispute between the Persico and Piloni families. It underwent extensive internal transformations over the centuries, and a severe fire in 1933 spared only the main façade. In 1941, based on a design by architect Alberto Alpago-Novello, it was rebuilt, restoring it to its 18th-century configuration. It is the headquarters of the Association of Industrialists of the province of Belluno.
