The Church of San Lorenzo, the main religious building in the northwest quadrant of the historic center, was built starting in 1280 on behalf of the Conventual Franciscan Friars.
On the outside, the church features a brick "wind" facade divided into two orders, marked by the imposing 14th-century portal by Andriolo de’ Santi.
The building has undergone expansions, transformations, and restorations, which, particularly in the 19th century, resulted in the relocation of various works, even outside its walls.
Inside the church, divided into three vaulted aisles, important paintings and sculptures are preserved. Among these: the Monument to Giambattista Porto and the Cenotaph of Vincenzo Scamozzi on the counter-facade; the 16th-century Gualdo Altar and the Deposition by Luca Giordano (late 17th-century copy) in the right aisle; the imposing Poiana Altar from the late 15th century in the right transept; the sculptural group by Antonino da Venezia with the Madonna and Child between Saints Peter and Paul in the left smaller chapel; the Madonna with Child and Saint Anthony of Padua by Giulio Carpioni, the Canati and Piovene altars in the left aisle.
The Municipality of Vicenza purchased the church in 1836, following the Napoleonic suppressions, becoming its owner.
The Conventual Franciscan Friars left the church in 2017. San Lorenzo is now run by the Minor Friars of the Gospel.
Like the Church of Santa Corona, the Temple of San Lorenzo is equipped with .
