The church was first mentioned in 1297 in the Rationes Decimarum. The church was probably built during the time of the Ezzelini, and its dedication to Saint George can be explained by the fact that, during the Middle Ages, the saint was the protector of cavalry, and his cult had a wide development throughout the West.
The warlike era of the Ezzelini da Romano - which ended in 1259 - could explain this dedication: the territory of Breganze was devoted, like the entire foothill area, to the great warrior family.
In 1571, during the Pastoral Visit, Bishop Ormaneto still found the old church standing, which had remained unchanged. In 1770, the construction of the new church began, which was still incomplete during the pastoral visit of Bishop Giustiniani in 1775. He described the old church as "very cramped" and destined in part to become the sacristy once the new church was completed, which, although incomplete, became operational in 1805.
Subsequently, in 1808, the facade and flooring were completed, in 1812 the spacious sacristy.
The parish of San Giorgio, linked to the church of Breganze for over a millennium, was separated in May 1818 when Pius VII returned Breganze to the Vicenza diocese. In 1866 and 1867, two new altars were added to the three pre-existing ones. The bell tower, which was temporarily replaced by a wooden one, was rebuilt in stone and tower-shaped between 1821 and 1828. The consecration of the church took place in 1889, and the following year it became a parish church.
In 1962, the church was restored and embellished. In 1992, work began on the roof and the external painting, in 1993, restoration work on the bell tower began, and in 1994, restoration work on the interior.
San Giorgio di Perlena, until a few years ago, served as a vicariate and included Calvene, Fara, Lugo, Mure, Salcedo, and San Giorgio.
