Particularly important for the religious history of Piove di Sacco is the Shrine of Madonna delle Grazie, located just outside the city's historic center. Externally, the place of worship shows a combination of different styles: the apse area, side walls and bell tower are in brick closer to the medieval taste, while the marble facade, decorated with a fresco of the Assumption, is a late 19th-century design by architect Giovanni Battista Tessari. It seems that a small convent of Franciscan friars existed in this place in the remote past, and the building of the present temple of "Our Lady of Grace" began around 1484.
According to legend, the two Sanguinazzi brothers went so far as to face each other in a duel to decide who would keep an image of the Madonna and Child inherited from their parents but were stopped by the pleading of a child who spoke in the name of God. The brothers were ordered to take the image to a chapel available to the entire community of believers.
The painting of the Virgin and Child, attributed to the Venetian painter Giovanni Bellini, is still the Sanctuary's major masterpiece. Other notable works include: also by Bellini, the altar of Our Lady of Grace, the Baroque-style main altar from 1683, the painting of the Annunciation in the main nave dating from 1649, and the remaining fragment with St. John the Evangelist and St. Anthony of Padua attributable to Angelo di Bartolomeo.
